For an oocyte to get ready for fertilization and expansion into an embryo, the correct set of genes really should be turned on. Namekawa suspected that this pre-programming on the oocyte genome comes about in various stages — the 1st a single starting throughout the time a feminine is born. He thought that chromatin remodeling proteins did A lot of the get the job done, by shifting spools around.
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Namekawa thinks that in human oocytes, variations in these patterns could disrupt the delicate choreography of genes getting turned on and off at the right periods — leaving them unprepared for fertilization or progress into nutritious embryos. Modifications in chromatin framework as an oocyte ages may also impact how that chromosomes segregate all through mobile division.
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